Across TCGA cell cohorts, RASGEF1A mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RASGEF1A-associated genes across cancer lineages are FAM47B, BRDT, and RASGEF1C. Each is linked with RASGEF1A in more than 1 cancer types. Because this analysis shows association rather than direction, both RASGEF1A-to-partner and partner-to-RASGEF1A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASGEF1A→partner) and Y-score (partner→RASGEF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FAM47B →	+0.006	+5.643	.003	.002	3	1
LARGE_INTESTINE	BRDT →	+0.066	+2.906	.009	.007	3	1
LARGE_INTESTINE	RASGEF1C →	+0.301	+3.626	<.001	.001	3	1
LARGE_INTESTINE	BPIFA1 →	+0.153	+3.425	<.001	<.001	3	1
LARGE_INTESTINE	IQCF6 →	+0.168	+2.882	.001	.005	3	1
LARGE_INTESTINE	PTTG2 →	+0.092	+3.497	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

RASGEF1A survival (RNA) · tumor vs normal (RNA) · all RASGEF1A data types