RASEF

Across TCGA patient cohorts, RASEF mutation is significantly associated with the RNA expression of many other genes, with 3,401 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RASEF-associated genes across cancer lineages are SCGB1D1, MTND4LP22, and RN7SL134P. Each is linked with RASEF in more than 2 cancer types. Because this analysis shows association rather than direction, both RASEF-to-partner and partner-to-RASEF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB1D1 grouped by RASEF-low versus RASEF-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASEF→partner) and Y-score (partner→RASEF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	SCGB1D1 →	+0.089	+4.602	<.001	.008	3	3
LGG	MTND4LP22 →	+0.137	+5.363	<.001	.003	3	3
LGG	RN7SL134P →	+0.189	+5.013	<.001	.002	3	3
CESC	RNU6-886P →	+0.462	+4.320	<.001	.007	3	3
CESC	RNA5SP198 →	+0.305	+5.144	<.001	.003	3	3
UCEC	RNA5SP436 →	+0.222	+2.559	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,401 associations by consensus.

SCGB1D1 by RASEF expression — LGG

Explore this box plot interactively →