RASAL3

Across TCGA cell cohorts, RASAL3 mutation is significantly associated with the RNA expression of many other genes, with 836 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RASAL3-associated genes across cancer lineages are DCLK3, KLK15, and C14orf178. Each is linked with RASAL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RASAL3-to-partner and partner-to-RASAL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCLK3 grouped by RASAL3-low versus RASAL3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASAL3→partner) and Y-score (partner→RASAL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DCLK3 →	+0.081	+4.139	.008	.001	3	2
SKIN	KLK15 →	+0.042	+2.994	<.001	.006	3	2
SKIN	C14orf178 →	+0.160	+4.013	<.001	.001	3	2
BLOOD_Leukemia	FAM149A →	+0.992	+3.672	<.001	<.001	3	2
LARGE_INTESTINE	INVS →	+0.589	+3.263	.008	.006	3	2
BLOOD_Leukemia	CENPL →	+0.610	+3.730	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 836 associations by consensus.

DCLK3 by RASAL3 expression — SKIN

Explore this box plot interactively →