RASA3-IT1

Across TCGA pan-cancer cohorts, RASA3-IT1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of RASA3-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where RASA3-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types RASA3-IT1 is over-expressed in tumor, although a few such as BLCA and KICH show the opposite, repressed pattern.

BLCA, KICH, and LUSC are the cancer types where RASA3-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RASA3-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	−0.986	.007	4	view →
KICH	All	II,III,IV	−0.084	.007	3	view →
LUSC	All	II,III,IV	−0.170	.024	2	view →
HNSC	Female	II,III,IV	+0.104	.043	2	view →
COAD	Male	III,IV	−0.361	.021	1	view →
LUAD	Male	All	+0.257	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

RASA3-IT1–BLCA

Open the BLCA breakdown →