RARS2

Across TCGA patient cohorts, RARS2 mutation is significantly associated with the RNA expression of many other genes, with 2,239 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RARS2-associated genes across cancer lineages are RNA5SP34, LINC00326, and FEM1AP1. Each is linked with RARS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RARS2-to-partner and partner-to-RARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP34 grouped by RARS2-low versus RARS2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RARS2→partner) and Y-score (partner→RARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP34 →	+0.175	+7.471	.009	.008	3	3
READ	LINC00326 →	+0.826	+5.421	<.001	.005	3	2
UCEC	FEM1AP1 →	+0.020	+2.368	<.001	.004	3	2
UCEC	MTRF1LP1 →	+0.100	+1.635	.003	.008	3	2
BRCA	MIR3675 →	+0.278	+7.471	<.001	.008	3	2
COAD	IGKV1OR9-1 →	+0.749	+4.624	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,239 associations by consensus.

RNA5SP34 by RARS2 expression — BRCA

Explore this box plot interactively →