RARS1

Across TCGA patient cohorts, RARS1 mutation is significantly associated with the RNA expression of many other genes, with 1,526 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RARS1-associated genes across cancer lineages are TYW1B, OPCML-IT2, and MFSD14C. Each is linked with RARS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RARS1-to-partner and partner-to-RARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TYW1B grouped by RARS1-low versus RARS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RARS1→partner) and Y-score (partner→RARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TYW1B →	+0.526	+3.491	.001	.002	3	2
SKCM	OPCML-IT2 →	+0.054	+4.212	<.001	.007	3	2
UCEC	MFSD14C →	+0.578	+2.906	<.001	.001	3	2
LUSC	RNU6-1067P →	+0.602	+4.792	<.001	.006	3	2
UCEC	ABL1 →	+0.539	+2.647	<.001	.005	3	2
SKCM	RNU6-905P →	+0.331	+3.776	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,526 associations by consensus.

TYW1B by RARS1 expression — UCEC

Explore this box plot interactively →