RARA

Across TCGA patient cohorts, RARA protein abundance is significantly associated with the RNA expression of many other genes, with 12,353 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible RARA-associated genes across cancer lineages are SPATA7, CSF2RB, and BIN2. Each is linked with RARA in more than 4 cancer types. Because this analysis shows association rather than direction, both RARA-to-partner and partner-to-RARA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RARA versus SPATA7 in CCRCC, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RARA→partner) and Y-score (partner→RARA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SPATA7 →	+0.539	+0.530	<.001	<.001	3	5
BRCA	CSF2RB →	-1.372	-0.620	<.001	.002	3	4
GBM	BIN2 →	-0.688	-0.644	<.001	<.001	3	4
UCEC	CD86 →	-0.852	-0.309	<.001	.001	3	4
BRCA	ARHGAP9 →	-0.631	-0.606	.007	.004	3	4
UCEC	STX11 →	-0.620	-0.375	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,353 associations by consensus.

RARA vs SPATA7 — CCRCC

Explore this scatter interactively →