RARA

Across TCGA pan-cancer cohorts, RARA RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of RARA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RARA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RARA is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KIRC, KICH, and THCA are the cancer types where RARA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RARA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.267	<.001	12	view →
KICH	All	III,IV	−1.887	<.001	10	view →
THCA	Male	All	+0.952	<.001	10	view →
HNSC	All	III,IV	+0.716	<.001	9	view →
LUSC	All	II,III,IV	−1.333	<.001	8	view →
LIHC	Female	II,III,IV	+1.249	<.001	7	view →
BLCA	Male	All	−1.016	<.001	7	view →
BRCA	All	III,IV	+1.224	<.001	6	view →
KIRP	All	IV	+1.132	.002	6	view →
LUAD	Male	All	−0.893	<.001	5	view →
STAD	Male	II,III,IV	+1.154	.003	4	view →
CHOL	All	All	+1.132	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

RARA–KIRC

Open the KIRC breakdown →