RARA

Across TCGA patient cohorts, RARA mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RARA-associated genes across cancer lineages are Caspase-7-cleavedD198, A-Raf_pS299, and PDCD4. Each is linked with RARA in more than 1 cancer types. Because this analysis shows association rather than direction, both RARA-to-partner and partner-to-RARA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by RARA-low versus RARA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RARA→partner) and Y-score (partner→RARA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+1.022	+3.479	<.001	.002	3	2
UCEC	A-Raf_pS299 →	-0.124	-3.000	.017	.036	3	1
UCEC	PDCD4 →	-0.563	-2.321	.006	.033	3	1
UCEC	PDK1_pS241 →	+0.159	+1.598	.033	.044	3	1
UCEC	Annexin-1 →	+0.536	+2.827	.019	.035	3	1
UCEC	ATM →	-0.784	-2.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Caspase-7-cleavedD198 by RARA expression — UCEC

Explore this box plot interactively →