RARA

Across TCGA cell cohorts, RARA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,910 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RARA-associated GO terms across cancer lineages are Epithelial cell fate commitment, mRNA transcription, and Positive regulation of T-helper 2 cell differentiation. Each is linked with RARA in more than 13 cancer types. Because this analysis shows association rather than direction, both RARA-to-partner and partner-to-RARA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epithelial cell fate commitment grouped by RARA-low versus RARA-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RARA→partner) and Y-score (partner→RARA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Epithelial cell fate commitment →	+0.221	+0.900	.006	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	mRNA transcription →	+0.071	+0.740	<.001	<.001	3	14
CNS	Positive regulation of T-helper 2 cell differentiation →	+0.815	+0.790	<.001	<.001	2	14
OVARY	mRNA transcription by RNA polymerase II →	+0.085	+1.023	<.001	<.001	3	13
BLOOD_Lymphoma	Positive regulation of leukocyte differentiation →	+0.074	+1.067	<.001	<.001	3	13
BLOOD_Lymphoma	Positive regulation of hemopoiesis →	+0.074	+1.067	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,910 associations by consensus.

Epithelial cell fate commitment by RARA expression — BLOOD_Lymphoma

Explore this box plot interactively →