RARA

Across TCGA cell cohorts, RARA mutation is significantly associated with the RNA expression of many other genes, with 77 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RARA-associated genes across cancer lineages are RLN3, OPALIN, and OR8K3. Each is linked with RARA in more than 1 cancer types. Because this analysis shows association rather than direction, both RARA-to-partner and partner-to-RARA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RLN3 grouped by RARA-low versus RARA-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RARA→partner) and Y-score (partner→RARA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RLN3 →	+0.049	+4.977	<.001	.007	3	1
SKIN	OPALIN →	+0.072	+4.977	<.001	.007	3	1
SKIN	OR8K3 →	+0.073	+4.977	<.001	.007	3	1
LARGE_INTESTINE	AVP →	+0.085	+5.217	<.001	<.001	3	1
LARGE_INTESTINE	PFN3 →	+0.169	+4.467	<.001	.004	3	1
BLOOD_Leukemia	HRH3 →	+0.021	+3.115	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

RLN3 by RARA expression — SKIN

Explore this box plot interactively →