RARA-AS1

Across TCGA pan-cancer cohorts, RARA-AS1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated RARA-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher RARA-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RARA-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and KICH show a favorable association.

UVM, UCS, and KICH are the cancer types where RARA-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	II,III,IV	0.431	0.741	<.001	103	view →
UCS	DFS	Quartile	III,IV	0.745	0.207	.002	84	view →
KICH	OS	Median	All	1.000	0.745	.001	50	view →
BRCA	OS	Tertile	III,IV	0.743	0.476	.002	30	view →
READ	DFS	Tertile	III,IV	0.803	0.344	.006	25	view →
SARC	DFS	Median	All	0.679	0.540	.003	22	view →
GBM	OS	Quartile	All	0.266	0.502	.007	12	view →
OV	DFS	Median	III,IV	0.121	0.185	.006	10	view →
LUAD	OS	Median	III,IV	0.727	0.578	.023	9	view →
THCA	OS	Quartile	II,III,IV	1.000	0.403	.028	9	view →
THYM	DFS	Tertile	III,IV	1.000	0.463	.030	8	view →
PRAD	DFS	Tertile	All	0.687	0.881	.020	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

RARA-AS1–UVM (DFS)

Open the UVM breakdown →