RARA-AS1

Across TCGA pan-cancer cohorts, RARA-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RARA-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RARA-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types RARA-AS1 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, THCA, and LIHC are the cancer types where RARA-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RARA-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−1.447	<.001	11	view →
THCA	Female	II,III,IV	+1.458	<.001	10	view →
LIHC	Female	All	+0.723	<.001	9	view →
LUAD	Female	All	−0.571	<.001	9	view →
LUSC	Male	III,IV	−1.447	<.001	8	view →
BLCA	All	All	−0.747	<.001	7	view →
UCEC	All	All	−0.864	<.001	6	view →
COAD	Female	All	−0.562	<.001	6	view →
CHOL	All	All	+0.891	<.001	3	view →
ESCA	All	All	+0.866	.003	3	view →
PRAD	All	All	−0.275	<.001	2	view →
KIRC	Female	All	+0.378	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RARA-AS1–KICH

Open the KICH breakdown →