RAPGEF6

Across TCGA patient cohorts, RAPGEF6 protein abundance is significantly associated with the RNA expression of many other genes, with 927 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible RAPGEF6-associated genes across cancer lineages are MRPS24, LRTM2, and LINC02873. Each is linked with RAPGEF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAPGEF6-to-partner and partner-to-RAPGEF6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RAPGEF6 versus MRPS24 in HNSC, with a Pearson correlation of -0.82.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF6→partner) and Y-score (partner→RAPGEF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MRPS24 →	-1.016	-0.788	.006	.007	3	2
OV	LRTM2 →	-0.376	-0.530	.008	.007	3	1
OV	LINC02873 →	-0.050	-0.530	<.001	.007	3	1
OV	RNU5E-4P →	-1.390	-0.530	<.001	.007	3	1
OV	TRBJ2-1 →	-2.573	-0.530	.002	.007	3	1
OV	TUBB3P1 →	-0.350	-0.530	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 927 associations by consensus.

RAPGEF6 vs MRPS24 — HNSC

Explore this scatter interactively →