RAPGEF6

Across TCGA cell cohorts, RAPGEF6 mutation is significantly associated with the RNA expression of many other genes, with 48 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RAPGEF6-associated genes across cancer lineages are NTSR2, BRDT, and H4C12. Each is linked with RAPGEF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAPGEF6-to-partner and partner-to-RAPGEF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NTSR2 grouped by RAPGEF6-low versus RAPGEF6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF6→partner) and Y-score (partner→RAPGEF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NTSR2 →	+0.047	+2.793	.001	.002	3	2
BLOOD_Leukemia	BRDT →	+0.120	+3.664	<.001	.001	3	2
LUNG_SCLC	H4C12 →	+0.697	+4.523	<.001	.003	3	2
LUNG_NSCLC_LUAD	SHCBP1L →	+0.664	+3.043	.001	.006	3	2
URINARY_TRACT	OR9K2 →	+0.020	+5.087	<.001	.004	3	1
URINARY_TRACT	CA5A →	+0.020	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

NTSR2 by RAPGEF6 expression — LARGE_INTESTINE

Explore this box plot interactively →