RAPGEF3

Across TCGA patient cohorts, RAPGEF3 RNA expression is significantly associated with the protein abundance of many other proteins, with 23,638 significant associations in total. GBM shows the largest number of these associations.

The most reproducible RAPGEF3-associated proteins across cancer lineages are POLR2H, PCDH1, and MAPK3. Each is linked with RAPGEF3 in more than 6 cancer types. Because this analysis shows association rather than direction, both RAPGEF3-to-partner and partner-to-RAPGEF3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RAPGEF3 versus POLR2H in LSCC, with a Pearson correlation of -0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF3→partner) and Y-score (partner→RAPGEF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	POLR2H →	-0.294	-0.426	<.001	<.001	3	7
HNSC	PCDH1 →	+0.501	+0.892	<.001	<.001	3	7
GBM	MAPK3 →	+0.402	+1.169	<.001	<.001	3	7
GBM	TOM1L2 →	+0.377	+0.625	<.001	<.001	3	6
LSCC	PRKDC →	-0.384	-0.633	<.001	<.001	3	6
BRCA	PTRH2 →	-0.331	-0.554	.004	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 23,638 associations by consensus.

RAPGEF3 vs POLR2H — LSCC

Explore this scatter interactively →