RAPGEF3

Across TCGA cell cohorts, RAPGEF3 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible RAPGEF3-associated genes across cancer lineages are OR2H1, TEX48, and CFC1. Each is linked with RAPGEF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAPGEF3-to-partner and partner-to-RAPGEF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2H1 grouped by RAPGEF3-low versus RAPGEF3-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAPGEF3→partner) and Y-score (partner→RAPGEF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR2H1 →	+0.022	+3.444	<.001	.003	3	2
SKIN	TEX48 →	+0.080	+3.920	.001	.005	3	2
CNS	CFC1 →	+0.078	+4.321	<.001	.009	3	1
CNS	CFC1B →	+0.010	+5.357	<.001	.001	3	1
CNS	CLRN1 →	+0.062	+4.169	<.001	.008	3	1
LARGE_INTESTINE	DRD3 →	+0.009	+3.562	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

OR2H1 by RAPGEF3 expression — OVARY

Explore this box plot interactively →