RAP2B

Across TCGA pan-cancer cohorts, RAP2B mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated RAP2B data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher RAP2B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RAP2B expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

COAD, PDAC, and HNSC are the cancer types where RAP2B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.877	1.000	.008	78	view →
PDAC	DFS	Tertile	All	0.279	0.503	<.001	59	view →
HNSC	DFS	Quartile	II,III,IV	1.000	0.864	.009	21	view →
LUAD	DFS	Quartile	II,III,IV	0.889	0.356	.002	6	view →
CCRCC	DFS	Quartile	III,IV	0.458	0.837	.032	5	view →
UCEC	DFS	Tertile	All	0.837	0.972	.020	4	view →
LSCC	DFS	Quartile	All	0.562	1.000	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

RAP2B–COAD (DFS)

Open the COAD breakdown →