RAP2B

Across TCGA pan-cancer cohorts, RAP2B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RAP2B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where RAP2B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RAP2B is over-expressed in tumor.

KIRP, KIRC, and HNSC are the cancer types where RAP2B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAP2B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+1.660	<.001	11	view →
KIRC	Male	All	+1.380	<.001	11	view →
HNSC	Male	All	+1.216	<.001	10	view →
THCA	Male	All	+0.567	<.001	9	view →
LUSC	Female	All	+1.543	<.001	8	view →
LUAD	Male	All	+0.686	<.001	8	view →
COAD	Male	All	+0.483	<.001	8	view →
LIHC	All	II,III,IV	+1.006	<.001	7	view →
BRCA	Female	II,III,IV	+0.475	<.001	6	view →
STAD	All	All	+0.696	.001	4	view →
CHOL	Male	All	+2.315	<.001	3	view →
READ	All	III,IV	+0.679	.040	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RAP2B–KIRP

Open the KIRP breakdown →