RAP1GDS1

Across TCGA pan-cancer cohorts, RAP1GDS1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RAP1GDS1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RAP1GDS1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types RAP1GDS1 is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

COAD, HNSC, and CCRCC are the cancer types where RAP1GDS1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAP1GDS1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−0.252	<.001	10	view →
HNSC	Male	II,III,IV	+0.169	<.001	8	view →
CCRCC	Male	III,IV	−0.135	<.001	7	view →
LUAD	Female	All	+0.214	<.001	6	view →
PDAC	Male	II,III,IV	+0.152	.022	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

RAP1GDS1–COAD

Open the COAD breakdown →