RAP1GAP

Across TCGA patient cohorts, RAP1GAP mutation is significantly associated with the RNA expression of many other genes, with 1,915 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAP1GAP-associated genes across cancer lineages are RNA5SP19, LINC01400, and LINC01997. Each is linked with RAP1GAP in more than 1 cancer types. Because this analysis shows association rather than direction, both RAP1GAP-to-partner and partner-to-RAP1GAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP19 grouped by RAP1GAP-low versus RAP1GAP-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAP1GAP→partner) and Y-score (partner→RAP1GAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP19 →	+0.362	+5.064	<.001	.004	3	2
BRCA	LINC01400 →	+0.069	+4.992	.001	.002	3	2
BRCA	LINC01997 →	+0.111	+5.162	<.001	.004	3	2
LUSC	RNU6-75P →	+0.309	+4.297	.001	.009	3	2
CESC	IGHVII-49-1 →	+0.195	+4.812	<.001	.006	3	2
LUAD	RNU6-650P →	+0.317	+3.742	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,915 associations by consensus.

RNA5SP19 by RAP1GAP expression — BRCA

Explore this box plot interactively →