RAP1GAP

Across TCGA pan-cancer cohorts, RAP1GAP RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated RAP1GAP data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher RAP1GAP RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RAP1GAP expression acts as an unfavorable survival marker, although some lineages such as COAD and KIRC show a favorable association.

UVM, LIHC, and LUSC are the cancer types where RAP1GAP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.364	0.838	<.001	88	view →
LIHC	OS	Tertile	All	0.577	0.766	<.001	72	view →
LUSC	OS	Quartile	III,IV	0.307	0.713	.004	56	view →
ACC	DFS	Tertile	All	0.199	0.790	<.001	46	view →
COAD	OS	Median	III,IV	0.857	0.538	<.001	45	view →
SKCM	OS	Tertile	III,IV	0.303	0.575	<.001	43	view →
KIRC	OS	Quartile	All	0.755	0.524	<.001	36	view →
MESO	DFS	Tertile	All	0.469	0.251	.009	28	view →
THYM	OS	Median	II,III,IV	0.727	1.000	.017	20	view →
KIRP	DFS	Median	III,IV	0.782	0.166	.013	20	view →
UCEC	DFS	Tertile	IV	0.372	0.713	.016	18	view →
ESCA	DFS	Median	III,IV	0.302	0.559	.002	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

RAP1GAP–UVM (DFS)

Open the UVM breakdown →