RAP1GAP

Across TCGA cell cohorts, RAP1GAP mutation is significantly associated with the RNA expression of many other genes, with 50 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RAP1GAP-associated genes across cancer lineages are TEX53, DEFB132, and OR11H6. Each is linked with RAP1GAP in more than 1 cancer types. Because this analysis shows association rather than direction, both RAP1GAP-to-partner and partner-to-RAP1GAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX53 grouped by RAP1GAP-low versus RAP1GAP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAP1GAP→partner) and Y-score (partner→RAP1GAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TEX53 →	+0.073	+2.777	<.001	.004	3	2
STOMACH	DEFB132 →	+0.084	+4.285	<.001	.007	3	2
CNS	OR11H6 →	+0.026	+4.321	<.001	.009	3	2
BLOOD_Lymphoma	FAM110D →	+0.107	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP9-2 →	+0.032	+5.247	<.001	.001	3	1
SOFT_TISSUE	CST9L →	+0.032	+5.369	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

TEX53 by RAP1GAP expression — LARGE_INTESTINE

Explore this box plot interactively →