RAP1BL

Across TCGA pan-cancer cohorts, RAP1BL RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated RAP1BL data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher RAP1BL RNA is associated with better overall survival. In most high-consensus cancer types, elevated RAP1BL expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

SKCM, UVM, and LGG are the cancer types where RAP1BL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	III,IV	0.551	0.279	<.001	71	view →
UVM	DFS	Quartile	III,IV	0.132	0.892	<.001	58	view →
LGG	OS	Median	All	0.364	0.547	<.001	49	view →
KIRC	DFS	Quartile	III,IV	0.775	0.333	.002	48	view →
READ	DFS	Tertile	All	0.709	0.258	.001	39	view →
MESO	OS	Median	All	0.256	0.707	.002	38	view →
HNSC	DFS	Median	All	0.659	0.540	.002	31	view →
CESC	DFS	Tertile	All	0.412	0.675	.003	28	view →
LUAD	DFS	Quartile	All	0.583	0.813	.005	27	view →
ESCA	DFS	Median	II,III,IV	0.293	1.000	.002	24	view →
BRCA	OS	Quartile	IV	0.981	0.257	.007	19	view →
LUSC	DFS	Median	III,IV	0.492	0.923	.003	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

RAP1BL–SKCM (OS)

Open the SKCM breakdown →