RAP1BL

Across TCGA pan-cancer cohorts, RAP1BL RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of RAP1BL’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RAP1BL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RAP1BL is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KICH, and THCA are the cancer types where RAP1BL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAP1BL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.945	<.001	11	view →
KICH	All	All	−0.664	<.001	6	view →
THCA	All	All	−0.304	.011	5	view →
READ	All	All	−0.807	.011	2	view →
CHOL	All	All	+0.763	.025	2	view →
BLCA	Male	All	−0.607	.047	2	view →
ESCA	Male	All	+0.872	.005	1	view →
LUAD	Female	III,IV	−0.638	.024	1	view →
LUSC	All	III,IV	−0.611	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

RAP1BL–HNSC

Open the HNSC breakdown →