RAP1B

Across TCGA pan-cancer cohorts, RAP1B mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RAP1B data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RAP1B mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RAP1B expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LUAD, UCEC, and HNSC are the cancer types where RAP1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.661	1.000	.004	19	view →
UCEC	DFS	Tertile	All	0.904	1.000	.022	12	view →
HNSC	DFS	Median	All	0.986	0.920	.011	12	view →
LSCC	DFS	Median	II,III,IV	0.845	0.988	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RAP1B–LUAD (OS)

Open the LUAD breakdown →