RAP1A

Across TCGA patient cohorts, RAP1A protein abundance is significantly associated with the RNA expression of many other genes, with 13,754 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RAP1A-associated genes across cancer lineages are CDC6, SKA1, and TOP2A. Each is linked with RAP1A in more than 7 cancer types. Because this analysis shows association rather than direction, both RAP1A-to-partner and partner-to-RAP1A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RAP1A versus CDC6 in LUAD, with a Pearson correlation of -0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAP1A→partner) and Y-score (partner→RAP1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CDC6 →	-0.830	-0.193	.002	.004	3	8
GBM	SKA1 →	-1.082	-0.361	<.001	<.001	3	7
GBM	TOP2A →	-1.445	-0.340	<.001	<.001	3	6
GBM	UBE2T →	-1.210	-0.385	<.001	<.001	3	6
LSCC	CENPI →	-0.843	-0.299	<.001	<.001	3	5
LSCC	MCM4 →	-0.759	-0.163	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,754 associations by consensus.

RAP1A vs CDC6 — LUAD

Explore this scatter interactively →