Across TCGA pan-cancer cohorts, RANP6 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of RANP6’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RANP6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RANP6 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
HNSC, COAD, and LUAD are the cancer types where RANP6 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RANP6 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.