Across TCGA pan-cancer cohorts, RANP5 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RANP5’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RANP5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RANP5 is over-expressed in tumor, although a few such as PAAD show the opposite, repressed pattern.

HNSC, COAD, and PAAD are the cancer types where RANP5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RANP5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+0.078	<.001	8	view →
COAD	All	All	+0.081	.002	4	view →
PAAD	Male	All	−0.145	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: RANP5 RNA expression & survival · all RANP5 data types