RANBP6

Across TCGA patient cohorts, RANBP6 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RANBP6-associated genes across cancer lineages are MEK1, INPP4B, and Caspase-7-cleavedD198. Each is linked with RANBP6 in more than 2 cancer types. Because this analysis shows association rather than direction, both RANBP6-to-partner and partner-to-RANBP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by RANBP6-low versus RANBP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RANBP6→partner) and Y-score (partner→RANBP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.377	+2.137	<.001	<.001	3	3
COAD	INPP4B →	-0.394	-3.169	.015	.018	3	2
COAD	Caspase-7-cleavedD198 →	+1.018	+2.467	.002	.011	2	3
UCEC	ATM →	-0.443	-1.643	.001	.003	3	2
UCEC	4E-BP1 →	+0.279	+3.807	<.001	<.001	3	2
UCEC	C-Raf →	+0.113	+1.765	.011	.013	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

MEK1 by RANBP6 expression — UCEC

Explore this box plot interactively →