RANBP10

Across TCGA patient cohorts, RANBP10 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RANBP10-associated genes across cancer lineages are A-Raf_pS299, FOXO3a_pS318_S321, and Ku80. Each is linked with RANBP10 in more than 1 cancer types. Because this analysis shows association rather than direction, both RANBP10-to-partner and partner-to-RANBP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by RANBP10-low versus RANBP10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RANBP10→partner) and Y-score (partner→RANBP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.210	-2.000	<.001	.032	3	2
UCEC	FOXO3a_pS318_S321 →	-0.151	-2.000	.007	.032	3	2
UCEC	Ku80 →	+0.230	+2.013	.030	.018	3	2
UCEC	p70-S6K_pT389 →	-0.225	-2.000	.008	.032	3	2
UCEC	EGFR_pY1068 →	-0.314	-2.459	.005	.019	3	1
UCEC	ERK2 →	+0.224	+2.000	.009	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

A-Raf_pS299 by RANBP10 expression — UCEC

Explore this box plot interactively →