RAMP1

Across TCGA pan-cancer cohorts, RAMP1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated RAMP1 data layer compared with 1 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher RAMP1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RAMP1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and THCA show a favorable association.

STAD, UVM, and COAD are the cancer types where RAMP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Quartile	All	0.549	0.905	<.001	86	view →
UVM	OS	Median	II,III,IV	0.375	0.799	<.001	78	view →
COAD	DFS	Median	II,III,IV	0.362	0.672	<.001	63	view →
BRCA	OS	Median	All	0.949	0.898	<.001	61	view →
KIRP	OS	Median	II,III,IV	0.608	0.880	.003	61	view →
READ	DFS	Tertile	All	0.350	0.695	.005	56	view →
OV	OS	Tertile	All	0.259	0.390	.002	34	view →
THCA	DFS	Quartile	All	0.965	0.920	.010	23	view →
CESC	DFS	Tertile	IV	0.576	0.120	.016	12	view →
ESCA	DFS	Quartile	All	0.571	0.345	.010	12	view →
LUAD	DFS	Tertile	All	0.619	0.757	.016	10	view →
SCLC	OS	Tertile	II,III,IV	0.476	0.795	.025	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

RAMP1–STAD (OS)

Open the STAD breakdown →