RAMAC

Across TCGA patient cohorts, RAMAC mutation is significantly associated with the RNA expression of many other genes, with 838 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAMAC-associated genes across cancer lineages are CHCHD2P3, LINC02427, and CWC25. Each is linked with RAMAC in more than 1 cancer types. Because this analysis shows association rather than direction, both RAMAC-to-partner and partner-to-RAMAC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHCHD2P3 grouped by RAMAC-low versus RAMAC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAMAC→partner) and Y-score (partner→RAMAC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHCHD2P3 →	+0.144	+2.188	.002	.007	3	1
UCEC	LINC02427 →	-0.308	-3.657	.004	.001	3	1
UCEC	CWC25 →	+0.509	+3.223	.002	.009	3	1
UCEC	CASTOR2 →	+1.123	+3.732	<.001	<.001	3	1
UCEC	RNA5SP414 →	+0.751	+2.407	<.001	.006	3	1
UCEC	TUBGCP5 →	+0.585	+3.507	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 838 associations by consensus.

CHCHD2P3 by RAMAC expression — UCEC

Explore this box plot interactively →