RAMAC

Across TCGA pan-cancer cohorts, RAMAC RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated RAMAC data layer compared with 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher RAMAC RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RAMAC expression acts as an unfavorable survival marker, although some lineages such as OV and KIRC show a favorable association.

KIRP, OV, and HNSC are the cancer types where RAMAC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	II,III,IV	0.156	0.711	<.001	88	view →
OV	DFS	Tertile	III,IV	0.435	0.306	<.001	82	view →
HNSC	DFS	Quartile	IV	0.170	0.510	.001	61	view →
KIRC	DFS	Tertile	All	0.854	0.715	.017	36	view →
LUSC	OS	Quartile	All	0.515	0.335	.003	35	view →
LGG	DFS	Quartile	All	0.729	0.886	<.001	27	view →
UVM	DFS	Tertile	III,IV	0.283	0.856	.007	21	view →
CHOL	DFS	Quartile	II,III,IV	0.180	0.779	.024	18	view →
UCS	DFS	Tertile	II,III,IV	0.562	0.208	.021	18	view →
BLCA	DFS	Quartile	All	0.286	0.605	.011	18	view →
SCLC	DFS	Tertile	All	0.666	1.000	.008	16	view →
BRCA	DFS	Median	III,IV	0.922	0.833	.010	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

RAMAC–KIRP (DFS)

Open the KIRP breakdown →