RALGDS

Across TCGA patient cohorts, RALGDS mutation is significantly associated with the RNA expression of many other genes, with 5,480 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RALGDS-associated genes across cancer lineages are LIN54, ZNF695, and PRC1. Each is linked with RALGDS in more than 2 cancer types. Because this analysis shows association rather than direction, both RALGDS-to-partner and partner-to-RALGDS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIN54 grouped by RALGDS-low versus RALGDS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RALGDS→partner) and Y-score (partner→RALGDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LIN54 →	+0.507	+1.868	<.001	<.001	3	3
UCEC	ZNF695 →	+0.365	+2.087	.008	.005	3	3
UCEC	PRC1 →	+0.749	+2.906	<.001	<.001	3	3
SKCM	BRD2 →	+0.572	+3.729	<.001	<.001	3	3
BLCA	RNU6-1077P →	+0.364	+3.665	.001	.001	3	3
UCEC	DHFR →	+0.737	+2.534	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,480 associations by consensus.

LIN54 by RALGDS expression — UCEC

Explore this box plot interactively →