RALA

Across TCGA patient cohorts, RALA mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RALA-associated genes across cancer lineages are eIF4E, A-Raf_pS299, and FASN. Each is linked with RALA in more than 1 cancer types. Because this analysis shows association rather than direction, both RALA-to-partner and partner-to-RALA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by RALA-low versus RALA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RALA→partner) and Y-score (partner→RALA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.212	+3.700	.005	.001	3	1
UCEC	A-Raf_pS299 →	-0.091	-1.807	.034	.025	3	1
UCEC	FASN →	+0.294	+1.700	.038	.042	3	1
UCEC	FoxM1 →	+0.238	+2.710	.010	.003	3	1
UCEC	Ku80 →	+0.274	+1.293	.001	.037	3	1
UCEC	Notch1 →	+0.174	+2.321	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

eIF4E by RALA expression — UCEC

Explore this box plot interactively →