RAI14

Across TCGA patient cohorts, RAI14 mutation is significantly associated with the RNA expression of many other genes, with 3,359 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAI14-associated genes across cancer lineages are RNU6-290P, MIR378E, and EIF2B2. Each is linked with RAI14 in more than 2 cancer types. Because this analysis shows association rather than direction, both RAI14-to-partner and partner-to-RAI14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-290P grouped by RAI14-low versus RAI14-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAI14→partner) and Y-score (partner→RAI14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-290P →	+0.132	+5.111	<.001	.001	3	3
SKCM	MIR378E →	+0.223	+4.575	<.001	<.001	3	3
UCEC	EIF2B2 →	+0.340	+1.754	<.001	<.001	3	3
UCEC	GTF2A2 →	+0.373	+1.743	.001	<.001	3	3
HNSC	H3Y2 →	+0.774	+4.624	<.001	.004	3	3
UCEC	MFSD12 →	+0.346	+2.565	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,359 associations by consensus.

RNU6-290P by RAI14 expression — LUSC

Explore this box plot interactively →