RAI14

Across TCGA patient cohorts, RAI14 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAI14-associated genes across cancer lineages are GAPDH, JNK_pT183_Y185, and MEK1. Each is linked with RAI14 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAI14-to-partner and partner-to-RAI14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by RAI14-low versus RAI14-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAI14→partner) and Y-score (partner→RAI14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	GAPDH →	+0.754	+2.816	.040	.036	3	2
UCEC	JNK_pT183_Y185 →	-0.113	-1.807	.021	.003	3	2
UCEC	MEK1 →	+0.293	+1.999	.005	.002	3	2
UCEC	Annexin-1 →	+0.538	+2.267	<.001	<.001	3	2
UCEC	Snail →	-0.184	-2.321	.048	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.475	+1.999	.005	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

GAPDH by RAI14 expression — LUSC

Explore this box plot interactively →