RAI1

Across TCGA cell cohorts, RAI1 mutation is significantly associated with the RNA expression of many other genes, with 846 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RAI1-associated genes across cancer lineages are IL22, FAM163B, and SH3GL2. Each is linked with RAI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAI1-to-partner and partner-to-RAI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL22 grouped by RAI1-low versus RAI1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAI1→partner) and Y-score (partner→RAI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	IL22 →	+0.023	+5.087	<.001	.004	3	2
CNS	FAM163B →	+0.060	+3.523	.003	.001	3	2
BLOOD_Leukemia	SH3GL2 →	+0.352	+3.505	.002	.001	3	2
LARGE_INTESTINE	FAM149A →	+1.089	+2.364	.001	<.001	3	2
BLOOD_Leukemia	RGS2 →	+1.359	+3.730	.001	<.001	3	2
LARGE_INTESTINE	KRAS →	+0.726	+3.043	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 846 associations by consensus.

IL22 by RAI1 expression — URINARY_TRACT

Explore this box plot interactively →