RAD54L

Across TCGA patient cohorts, RAD54L mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAD54L-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and EGFR. Each is linked with RAD54L in more than 1 cancer types. Because this analysis shows association rather than direction, both RAD54L-to-partner and partner-to-RAD54L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by RAD54L-low versus RAD54L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD54L→partner) and Y-score (partner→RAD54L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.702	+2.434	.001	.001	3	2
UCEC	14-3-3_beta →	-0.072	-1.847	.049	.049	3	1
UCEC	EGFR →	-0.164	-2.459	.005	.019	3	1
UCEC	A-Raf_pS299 →	-0.151	-1.678	<.001	.021	3	1
UCEC	ERK2 →	+0.198	+1.847	.005	.008	3	1
UCEC	JNK2 →	+0.234	+1.594	.001	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Caspase-7-cleavedD198 by RAD54L expression — UCEC

Explore this box plot interactively →