RAD54L

Across TCGA cell cohorts, RAD54L mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RAD54L-associated genes across cancer lineages are DIRC1, URAD, and GNG8. Each is linked with RAD54L in more than 1 cancer types. Because this analysis shows association rather than direction, both RAD54L-to-partner and partner-to-RAD54L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DIRC1 grouped by RAD54L-low versus RAD54L-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD54L→partner) and Y-score (partner→RAD54L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DIRC1 →	+0.018	+4.510	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	URAD →	+0.017	+4.357	<.001	.006	3	1
LUNG_NSCLC_LUAD	GNG8 →	+0.244	+4.887	.003	.009	3	1
LUNG_NSCLC_LUAD	CNGA2 →	+0.036	+4.887	<.001	.009	3	1
BLOOD_Leukemia	ZIC3 →	+0.012	+3.890	<.001	<.001	3	1
BLOOD_Leukemia	IL1RAPL2 →	+0.210	+3.359	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

DIRC1 by RAD54L expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →