RAD52

Across TCGA patient cohorts, RAD52 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAD52-associated genes across cancer lineages are Tuberin_pT1462, 14-3-3_beta, and GAPDH. Each is linked with RAD52 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAD52-to-partner and partner-to-RAD52 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin_pT1462 grouped by RAD52-low versus RAD52-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD52→partner) and Y-score (partner→RAD52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin_pT1462 →	+0.244	+2.817	.035	.036	3	2
UCEC	14-3-3_beta →	-0.135	-2.973	.007	.035	3	1
UCEC	GAPDH →	+0.564	+3.169	.036	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.227	-2.308	.007	.036	3	1
UCEC	Ku80 →	+0.407	+3.472	<.001	.002	3	1
UCEC	PCNA →	+0.320	+2.321	.003	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Tuberin_pT1462 by RAD52 expression — UCEC

Explore this box plot interactively →