RAD52

Across TCGA pan-cancer cohorts, RAD52 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RAD52’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where RAD52 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RAD52 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

LIHC, HNSC, and BRCA are the cancer types where RAD52 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAD52 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+0.773	<.001	8	view →
HNSC	All	All	+0.351	<.001	8	view →
BRCA	Female	All	−0.224	.005	6	view →
CHOL	Male	All	+2.116	<.001	5	view →
KICH	Female	All	−1.060	<.001	5	view →
BLCA	All	All	+0.392	.024	5	view →
LUSC	All	All	+0.433	<.001	4	view →
KIRP	All	IV	+1.050	.009	2	view →
THCA	All	II,III,IV	−0.362	.018	2	view →
KIRC	All	All	+0.183	.010	2	view →
STAD	Male	II,III,IV	+0.528	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RAD52–LIHC

Open the LIHC breakdown →