RAD52

Across TCGA cell cohorts, RAD52 mutation is significantly associated with the mutation status of many other genes, with 645 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RAD52-associated genes across cancer lineages are FNBP4, POP1, and GARS1. Each is linked with RAD52 in more than 2 cancer types. Because this analysis shows association rather than direction, both RAD52-to-partner and partner-to-RAD52 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FNBP4 grouped by RAD52-low versus RAD52-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD52→partner) and Y-score (partner→RAD52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FNBP4 →	+4.977	+5.638	<.001	<.001	1	3
LARGE_INTESTINE	POP1 →	+2.284	+3.925	.005	.005	1	2
LARGE_INTESTINE	GARS1 →	+3.329	+3.799	.005	.005	1	2
LARGE_INTESTINE	KANK1 →	+2.159	+3.807	.007	.007	1	2
SKIN	TBC1D20 →	+4.392	+4.392	.009	.009	1	2
LARGE_INTESTINE	COPB1 →	+3.007	+3.584	.008	.008	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 645 associations by consensus.

FNBP4 by RAD52 expression — SKIN

Explore this box plot interactively →