RAD51C

Across TCGA patient cohorts, RAD51C mutation is significantly associated with the RNA expression of many other genes, with 322 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAD51C-associated genes across cancer lineages are OR8B6P, MIR606, and NRON. Each is linked with RAD51C in more than 2 cancer types. Because this analysis shows association rather than direction, both RAD51C-to-partner and partner-to-RAD51C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B6P grouped by RAD51C-low versus RAD51C-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD51C→partner) and Y-score (partner→RAD51C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	OR8B6P →	+0.043	+3.043	<.001	.003	3	3
BLCA	MIR606 →	+0.298	+3.043	<.001	.003	3	2
LUSC	NRON →	+0.348	+4.339	<.001	.007	3	2
SKCM	MIR4688 →	+0.295	+3.809	<.001	.003	3	2
CESC	FDX1P2 →	+0.094	+4.812	<.001	.006	3	2
CESC	CBX3P6 →	+0.096	+5.144	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 322 associations by consensus.

OR8B6P by RAD51C expression — BLCA

Explore this box plot interactively →