RAD51C

Across TCGA pan-cancer cohorts, RAD51C RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of RAD51C’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RAD51C RNA is repressed in tumor relative to normal tissue. In most cancer types RAD51C is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, LIHC, and COAD are the cancer types where RAD51C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAD51C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.479	<.001	9	view →
LIHC	Male	All	+0.992	<.001	9	view →
COAD	Female	II,III,IV	+0.688	<.001	9	view →
LUAD	Male	II,III,IV	+0.546	<.001	9	view →
HNSC	Male	IV	+0.931	<.001	8	view →
LUSC	Female	All	+0.882	<.001	7	view →
THCA	All	All	−0.270	<.001	7	view →
BRCA	All	II,III,IV	+0.418	<.001	6	view →
CHOL	Male	All	+1.553	<.001	5	view →
KIRP	All	II,III,IV	+0.484	.006	5	view →
READ	Male	All	+0.400	.027	3	view →
BLCA	All	All	+0.353	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

RAD51C–KICH

Open the KICH breakdown →