RAD51C

Across TCGA patient cohorts, RAD51C mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAD51C-associated genes across cancer lineages are JNK_pT183_Y185, p70-S6K_pT389, and Paxillin. Each is linked with RAD51C in more than 1 cancer types. Because this analysis shows association rather than direction, both RAD51C-to-partner and partner-to-RAD51C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by RAD51C-low versus RAD51C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD51C→partner) and Y-score (partner→RAD51C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.198	-3.169	.015	.019	3	1
UCEC	p70-S6K_pT389 →	-0.204	-2.459	.026	.020	3	1
UCEC	Paxillin →	+0.308	+2.179	.014	.034	3	1
UCEC	Di-Ras3 →	-0.171	-3.000	.017	.036	3	1
UCEC	ERK2 →	+0.240	+2.459	.009	.020	2	1
UCEC	MSH2 →	-0.413	-3.312	<.001	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

JNK_pT183_Y185 by RAD51C expression — UCEC

Explore this box plot interactively →