RAD51C

Across TCGA cell cohorts, RAD51C RNA expression is significantly associated with the go_rna of many other GO terms, with 4,337 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RAD51C-associated GO terms across cancer lineages are DNA-templated DNA replication, Regulation of mitotic metaphase/anaphase transition, and Regulation of sister chromatid segregation. Each is linked with RAD51C in more than 17 cancer types. Because this analysis shows association rather than direction, both RAD51C-to-partner and partner-to-RAD51C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated DNA replication grouped by RAD51C-low versus RAD51C-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD51C→partner) and Y-score (partner→RAD51C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.155	+1.601	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Regulation of mitotic metaphase/anaphase transition →	+0.141	+1.447	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Regulation of sister chromatid segregation →	+0.136	+1.590	<.001	<.001	3	17
BREAST	Centrosome cycle →	+0.088	+1.217	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Positive regulation of G2/M transition of mitotic cell cycle →	+0.142	+1.488	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Regulation of metaphase/anaphase transition of cell cycle →	+0.137	+1.529	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,337 associations by consensus.

DNA-templated DNA replication by RAD51C expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →