RAD50

Across TCGA patient cohorts, RAD50 mutation is significantly associated with the RNA expression of many other genes, with 3,951 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAD50-associated genes across cancer lineages are RFC4, PIGW, and RRM1. Each is linked with RAD50 in more than 3 cancer types. Because this analysis shows association rather than direction, both RAD50-to-partner and partner-to-RAD50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFC4 grouped by RAD50-low versus RAD50-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD50→partner) and Y-score (partner→RAD50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RFC4 →	+0.431	+1.807	.003	<.001	3	4
UCEC	PIGW →	+0.422	+1.638	.001	<.001	3	3
UCEC	RRM1 →	+0.725	+2.000	<.001	<.001	3	3
UCEC	FEN1 →	+0.656	+1.660	<.001	<.001	3	3
UCEC	CKAP2L →	+0.506	+1.917	.001	<.001	3	3
UCEC	ESCO2 →	+0.557	+2.123	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,951 associations by consensus.

RFC4 by RAD50 expression — UCEC

Explore this box plot interactively →