RAD23A

Across TCGA patient cohorts, RAD23A mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAD23A-associated genes across cancer lineages are MSH2, VHL, and IGFBP2. Each is linked with RAD23A in more than 1 cancer types. Because this analysis shows association rather than direction, both RAD23A-to-partner and partner-to-RAD23A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by RAD23A-low versus RAD23A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD23A→partner) and Y-score (partner→RAD23A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.357	-3.459	.002	.005	3	1
UCEC	VHL →	-0.819	-2.321	.016	.035	3	1
UCEC	IGFBP2 →	-1.059	-3.169	.001	.019	2	1
UCEC	IRS1 →	+0.249	+2.321	.016	.035	2	1
UCEC	Lck →	+0.221	+2.321	.028	.035	2	1
UCEC	Shc_pY317 →	-0.176	-3.459	.020	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MSH2 by RAD23A expression — UCEC

Explore this box plot interactively →